Researchers have discovered gene involved in deregulation of immune cells

Q.  Researchers have discovered a gene involved in deregulation of immune cells in neurological disease MS. What is it called?
- Published on 30 May 16

a. ANKRD56
b. ANDRK55
c. ANKRD55
d. None of the above

ANSWER: ANKRD55
 
Researchers have discovered a gene involved in the deregulation of certain immune cells in neurological disease MS. Characterised by the onset of chronic, neurodegenerative damage of the CNS, this disabling disease disrupts flow of information within the brain and between the brain and body by attacking the protective sheet (myelin) covering nerve fibres.
  • Causes of MS are unknown though various self immune mechanisms are known to be involved
  • Researchers know genetic variants lead to changes in code of DNA component and to understand their biological effects, effect of expression of corresponding gene needs to be studied.
  • Research shows gene ANKRD55 produces three different transcripts of the messenger RNA and the genetic variant associated with MS greatly increases the production of these transcripts
  • It has also been discovered and proven that this occurs specifically in the case of certain category of immune cells called TCD4+ feels
  • ANKRD55 exerts significant biological function on these cells and now needs to be deciphered.

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